Blood cells – Communicable Diseases Research

Novel aspects of sepsis pathophysiology: NETs, plasma glycoproteins, endotheliopathy and COVID-19

Review article

Published on 2022-09-012022-10-05
Journal: Journal of pharmacological sciences
[Category] 바이오마커,

Innate immune response analysis in COVID-19 and kawasaki disease reveals MIS-C predictors

COVID-19 및 가와사키병의 타고난 면역 반응 분석은 MIS-C 예측 인자를 밝힙니다

Article

Published on 2022-03-012022-09-11
Journal: Journal of the Formosan Medical Association = Taiw
[Category] SARS, 변종, 치료기술,

[키워드] acute SARS-CoV-2 infection Adults analyses Analysis ArrayExpress association Blood blood cell Blood cells CASP1 CD14 CD36 children Cohort correlated COVID-19 COVID-19 diagnosis COVID-19 severity dataset determine disease downloaded dysregulated dysregulation enriched pathway enriched pathways expression level FCGR2A gene expression signature genetic polymorphisms HLA-DOB IFI16 IFNAR1 immune dysregulation immune response immune responses increased expression Inflammatory Innate innate immune innate immune gene innate immune genes innate immune response Innate immunity Interaction interactions irak4 IRF3 Kawasaki disease MIS-C moderate multisystem inflammatory syndrome. network network analysis NLRP3 pathway Patient PELI1 polymorphism predict predictor predisposition Pycard reveal SARS-CoV-2 infections severe COVID-19 severity STAT3 STING susceptibility syndrome TLR2 TLR7 TLR8 Transcriptome transcriptome datasets transcriptomes variant variants was used with COVID-19
[DOI] 10.1016/j.jfma.2021.06.009 PMC 바로가기 [Article Type] Article

Implication of COVID-19 on Erythrocytes Functionality: Red Blood Cell Biochemical Implications and Morpho-Functional Aspects

적혈구 기능에 대한 COVID-19의 의미: 적혈구 생화학적 의미 및 형태-기능적 측면

Review

Published on 2022-02-162022-09-10
Journal: International Journal of Molecular Sciences
[Category] MERS, 치료제,

[키워드] Affect alteration Anemia antioxidant aspect Blood blood cell Blood cells Cancer cause causes Cell change changes changes in Concentration Course COVID COVID-19 COVID-19 severity diabetes disease disease severity distribution enzyme erythrocyte erythrocytes evaluated focus help hematological hematological changes hematology hemoglobin increase in infections information Long Lower management metabolism morphology neurodegenerative disorders oxidative stress patients with COVID-19 Prevent progressed progression promote Red red blood cells reported rigidity risk SARS-CoV-2 severe COVID-19 shown the disease Viral viral infection worsening
[DOI] 10.3390/ijms23042171 PMC 바로가기 [Article Type] Review

Super interactive promoters provide insight into cell type-specific regulatory networks in blood lineage cell types

슈퍼 대화식 프로모터는 혈액 계통 세포 유형에서 세포 유형-특이 적 조절 네트워크에 대한 통찰력을 제공

Research Article

Published on 2022-01-312022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] Analysis analysis ATAC-seq binding Blood blood cell Blood cells capture CD4 Cell cell type cell types chromatin compendium complex Critical disrupt driven by enhancer enhancers EPHB3 ETS1 explain Express expression level FIVE Follow-up functional Genetic variant GWAS GWAS variant GWAS variants help hematological hypothese identify implication include independent Interaction interactions interactivity Interpretation Lineage locus lymphocyte Lymphocyte count motifs norm overlap Phenotypes PIR Platelet Platelet count promoter promoters provide redundancy Region regions Regulatory regulatory network regulatory region resource strong interactions traits transcription factor transcriptional transcriptional regulation variant variants
[DOI] 10.1371/journal.pgen.1009984 PMC 바로가기 [Article Type] Research Article

A systematic review of outcomes in COVID-19 patients treated with western medicine in combination with traditional Chinese medicine versus western medicine alone

중국 의약과 서양 의학만으로도 서양 의학으로 치료받은 Covid-19 환자의 결과에 대한 체계적인 검토

Review

Published on 2022-01-062022-08-31
Journal: Expert reviews in molecular medicine
[Category] SARS, 임상, 치료제,

[키워드] 95% CI 95% confidence interval analysed Blood Blood cells CBM CENTRAL Chest computed tomography Chest CT China China Clinical Trial Registry Chinese Chinese Biomedical Literature Database clinical clinical outcomes clinical trial CNKI Combination complementary Computed tomography control group Controlled controlled trials coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) cough country COVID-19 COVID-19 patient COVID-19 patients cure rate database death determine effective experimental group Fever forest plot forest plots global pandemic include Infrastructure integrated Chinese with western (ICW) Intervention lack less literature lymphocyte Lymphocytes mean difference meta-analyses Meta-analysis meta-analysis no statistical difference nucleic acid number of deaths outbreak outcome Patient public health Quantitative data Random-effects models randomised controlled registry Research risk risk of bia RoB searched significantly statistical analysis Symptom systematic review TCM Traditional Chinese medicine traditional Chinese medicine (TCM) treated Treatment Treatment outcome trials Viral viral nucleic acid was used WBC WBCs were assessed were used western medicine (WM). White blood cell White blood cells
[DOI] 10.1017/erm.2021.35 PMC 바로가기 [Article Type] Review

Thrombosis-related circulating miR-16-5p is associated with disease severity in patients hospitalised for COVID-19

혈전증 관련 순환 miR-16-5p는 COVID-19로 입원한 환자의 질병 중증도와 관련이 있습니다

Article

Published on 2022-01-012022-09-11
Journal: RNA Biology
[Category] 바이오마커,

[키워드] 95% CI ACE2 ACE2 receptor activated acute respiratory syndrome acute respiratory syndrome coronavirus Admission amyloid amyloid beta Analysis angiotensin Angiotensin-converting enzyme app approach Area baseline baseline expression Beta bioinformatic analysis bioinformatics Bioinformatics analysis Biomarker Blood Blood cells body mass CALM1 calmodulin can be used changes in chronic obstructive circulating class Co-expression analysis Coagulation composite endpoint condition Control Coronary artery coronavirus coronavirus disease Coronavirus infection COVID-19 COVID-19 complications COVID-19 patient cyclin dataset death diabete diabetes Diabetes Mellitus diagnostic disease disease severity EGFR ELAVL1 enzyme expression expression level expression levels expressions family Fibronectin Filamin FLNA FN1 Follow-up Gene Expression Genes growth factor healthy controls healthy volunteer heat Heat shock heat shock protein hospital hospitalised hospitalized COVID-19 patient HSP90AA1 Human hypercoagulable in silico in silico prediction independent predictor independent predictors individual inflammatory reaction intensive care interquartile let-7b-5p Like member microRNA MicroRNAs microRNAs. miR-155 miR-16-5p miRNA miRNAs Multivariate analysis Myocardial nuclear pathway Pathways Patient patients hospitalized patients with COVID-19 performed peripheral Peripheral blood phosphatase play role polymerase chain positive Predictive prognostic biomarker Prognostic biomarkers Protein PTEN qRT-PCR Quantitative receptor Regulatory RNA SARS-CoV-2 selected Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Severity of infection silico prediction silico predictions Stratification tensin the healthy THROMBOPLASTIN thrombosis thrombotic Toll-like receptor TP53 UBC ubiquitin utility White blood cells
[DOI] 10.1080/15476286.2022.2100629 PMC 바로가기 [Article Type] Article

Systems Biology and Bioinformatics approach to Identify blood based signatures molecules and drug targets of patient with COVID-19

Research article

Published on 2021-12-302022-10-05
Journal: Informatics in Medicine Unlocked
[Category] 바이오마커,

[키워드] acute respiratory syndrome approach association AURKB bioinformatics Biology Biomarker Biomarker signatures Blood blood cell Blood cells Blood common gene BUB1B CCNB1 Cell connection contagious Coronavirus-2 COVID-19 dataset DEGs diagnose differentially expressed gene Differentially expressed genes disease DLGAP5 drug target effective Gene Expression Gene ontology HJURP hub protein Identified identify infected with SARS-CoV-2 Infection KIF11 Microarray molecular MONITOR mononuclear cell NCAPG New coronavirus Ontology pathophysiology pathway patient with COVID-19 patients with COVID-19 PBMCs PBMCs cell performed Peripheral blood prevalence of COVID-19 progression Research SARS-CoV-2 signaling pathways subjects System therapeutic intervention TOP2A TPX2 transcript transcriptomic Treatment TTK with COVID-19
[DOI] 10.1016/j.imu.2021.100840 [Article Type] Research article

MicroRNAs are minor constituents of extracellular vesicles that are rarely delivered to target cells

microRNA는 표적 세포로 거의 전달되지 않는 세포 외 소포의 작은 성분입니다.

Research Article

Published on 2021-12-062022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] Affect Alter analyzed applied approach Biological functions Blood cells carried Cell cell line cell lines cell types cell-to-cell communication cellular cellular membrane cellular membranes contribute defined document effector effectors Evidence EVs Exosome Exosomes experiments extracellular vesicle Extracellular vesicles fraction functional FUSE had no majority mammalian cells messenger RNAs microRNA MicroRNAs Microvesicles miRNA miRNAs mRNA mRNAs packaged purified Quantitative recipient regulate RNAs Sensitivity and specificity stability target target cell target cells target mRNA Transcriptome Vesicle vesicles Viral viral miRNAs
[DOI] 10.1371/journal.pgen.1009951 PMC 바로가기 [Article Type] Research Article

Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patients

PBMC에 의한 포스파티딜세린 양성 미세입자의 결합은 COVID-19 환자의 질병 중증도를 분류합니다

Article

Published on 2021-12-012022-09-11
Journal: Journal of Extracellular Vesicles
[Category] 유전자 메커니즘,

[키워드] activated addition Affect Apoptosis blood cell Blood cells Blood coagulation carried cascade CD8 CD8+ CD8+ T cells cells Clinical course Coagulation complement complement system correlated strongly COVID-19 COVID-19 diagnosis COVID-19 patient COVID-19 patients disease severity distribution dying cells Frequency gene expression signature immune cells immune dysfunction Inflammation Inflammatory responses initial investigated Laboratory leucocyte lymphocyte Lymphocytes lymphopenia marker memory T cells Microparticle occur Patient PBMC PBMCs PD-L1 Phosphatidylserine Platelet platelet-derived microparticle Platelets SARS-CoV-2 severe lymphopenia T cell T cells Thromboinflammation thromboinflammation. thrombotic
[DOI] 10.1002/jev2.12173 PMC 바로가기 [Article Type] Article

In silico drug repurposing in COVID-19: A network-based analysis

Covid-19의 Silico Drug Reperhing에서 : 네트워크 기반 분석

Article

Published on 2021-10-012022-08-31
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar
[Category] MERS, 신약개발, 임상, 치료제,

[키워드] addition Analysis analyzed antibodies Anticoagulants approach Blood cells bowel Central nervous system clinical clinical setting clinical trial clinical trials compounds conditions Corticosteroid Corticosteroids corticosteroids) COVID-19 COVID-19 patient COVID-19 patients de novo drug Drug discovery Drug repurposing examined faster healthy subjects heparin identify Inflammatory bowel disease inhibitor mandatory patients with COVID-19 priority public health emergency SARS-CoV-2 pandemic SCN5A septic Septic shock Septic shock. Shock transcriptomic data treat vaccination whole blood cell whole blood cells
[DOI] 10.1016/j.biopha.2021.111954 PMC 바로가기 [Article Type] Article